참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| 반응물 | 4-Mercaptohydrocinnamic Acid | HCID 579784 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-[4-(5-Nitropyridin-2-ylsulfanyl)phenyl]propionic acid | HCID 68527099 | — |
반응 단계
To a solution of 2-chloro-5-nitropyridine (1.74 g, 11.0 mmol) and 4-mercaptohydrocinnamic acid (2.00 g, 11.0 mmol) in DMF (30 mL) was added potassium carbonate (4.55 g, 32.9 mmol), and the resulting solution was stirred for 1 hour at 80° C. To the reaction solution were added water and concentrated hydrochloric acid, and then cooled with ice. The precipitated solid matter was collected by filtration, to thereby yield 3.29 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08236826B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_08 |
|---|
| ORD ID | ord-5f3c21d9283e4d918f14deccd368ebf2 |
|---|
| 출처 메모 | uspto-grants-2012_08 |
|---|
