Chlorotrimethylsilane → HCID 178452187, 화합물

HRID 884341노트

반응식

HRID 884341 반응식
[Zn:1].C[Si](Cl)(C)C.BrCCBr.[C:11]([O:15][C:16]([N:18]1[CH2:21][CH:20]([I:22])[CH2:19]1)=[O:17])([CH3:14])([CH3:13])[CH3:12]>CC(N(C)C)=O>[I-:22].[C:11]([O:15][C:16]([N:18]1[CH2:21][CH:20]([Zn+:1])[CH2:19]1)=[O:17])([CH3:14])([CH3:13])[CH3:12]

참가 물질

6

반응물 4

HCID 6397ChlorotrimethylsilaneHCID 78391,2-DibromoethaneHCID 23994ZincHCID 11000522Tert-butyl 3-iodoazetidine-1-carboxylate

생성물 1

HCID 178452187HCID 178452187, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매2회

반응 조건

온도
65 °C

실험 절차

Zn dust (1.80 g, 27.5 mmol) was vigorously stirred in DMA (11 ml) under nitrogen and the suspension was heated at 65° C. Trimethylsilyl chloride (0.37 g, 3.39 mmol) and 1,2-dibromoethane (0.64 g, 3.39 mmol) was added and stirring continued for 40 min. A solution of 3-iodo-azetidine-1-carboxylic acid tert-butyl ester (6.00 g, 21.2 mmol) in dimethylacetamide (DMA, 10 ml) was then added dropwise to the solution over a period of 30 min and then the reaction mixture allowed to cool to room temperature over 16 h. The resulting solution was used without any purification in the next step.

후처리

  1. temperatureto cool to room temperature over 16 h
  2. customThe resulting solution was used without any purification in the next step

출처 및 근거

ORD 기록
ord-6dd1cd814a2a4d8bb3e005b5d492320c
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242102B2

반응 노트

불러오는 중…