홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 25110613, 화합물

HRID 885148
노트
인쇄 미리보기

반응식

HRID 885148 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:31])[CH2:11][N:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]=[C:26]([CH3:28])[N:25]=[CH:24]4)=[C:19]([O:29][CH3:30])[CH:18]=3)[N:14]=[N:13]2)[CH:5]=[CH:6][C:7]=1[F:8].C[Si]([N-][Si](C)(C)C)(C)C.[K+].[O:42]([CH2:50][C:51]([F:54])([F:53])[F:52])S(C(F)(F)F)(=O)=O>CN(C=O)C>[F:52][C:51]([F:54])([F:53])[C:50]([OH:29])=[O:42].[Cl:1][C:2]1[CH:3]=[C:4]([N:9]([CH2:50][C:51]([F:54])([F:53])[F:52])[C:10](=[O:31])[CH2:11][N:12]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]=[C:26]([CH3:28])[N:25]=[CH:24]4)=[C:19]([O:29][CH3:30])[CH:18]=3)[N:14]=[N:13]2)[CH:5]=[CH:6][C:7]=1[F:8]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 3251421Potassium bis(trimethylsilyl)amideHCID 59472622HCID 59472622, 화합물

생성물 1

HCID 25110613HCID 25110613, 화합물수율 69.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-(3-chloro-4-fluorophenyl)-2-{-4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}acetamide (50 mg, 0.113 mmol) and KHMDS (27.1 mg, 0.136 mmol) were added to a 25-mL flask under nitrogen and DMF (3 ml) was added. Trifluoroethyl triflate (0.023 ml, 0.159 mmol) was added and the suspension stirred at room temperature for 16 h. The residue was purified by preparative HPLC Reverse phase (C-18), eluting with Acetonitrile/Water+0.1% TFA, to give the product (25 mg) as a yellow solid.

후처리

  1. customThe residue was purified by preparative HPLC Reverse phase (C-18)
  2. washeluting with Acetonitrile/Water+0.1% TFA

출처 및 근거

ORD 기록
ord-d87a5af84682435fad05e5523697ca92
출처 데이터셋
uspto-grants-2012_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08242150B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트