Ethanol → (5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester

HRID 885286노트

반응식

HRID 885286 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([Cl:19])=[C:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:25][CH2:26]O>>[CH2:25]([O:17][C:16](=[O:18])[CH2:15][C:13]1[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=[CH:11][C:12]=1[Cl:19])[CH3:26]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 58149280(5-Benzyloxy-2-chloro-phenyl)-acetic acid

생성물 1

HCID 58148945(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester

실험 절차

To (5-benzyloxy-2-chloro-phenyl)-acetic acid (1.5 g, 5.4 mmol) in EtOH (30 mL) was added sulfuric acid (1 mL), and the mixture was stirred overnight at room temperature. Once no starting material was seen by analytical LCMS, the reaction was worked up to give the desired product (1.7 g).

출처 및 근거

ORD 기록
ord-4ea0a002f821468680f898a07d33da0e
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242145B2

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