Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Baclofen → 4-(4-Chlorophenyl)-2-pyrrolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Baclofen | HCID 2284 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(4-Chlorophenyl)-2-pyrrolidinone | HCID 185490 | — |
반응 단계
To Baclofen (1.0 g, 4.7 mmol) in CH2Cl2 (20 mL) was added thionyl chloride (0.38 mL, 5.2 mmol), and the reaction was stirred for 10 minutes. Diisopropylethylamine (1.5 mL) was added, and the mixture was worked-up to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08242145B2 |
| 출처 데이터셋 | uspto-grants-2012_08 |
| ORD ID | ord-417fc5766c154604aeaddd8638a0c2ee |
| 출처 메모 | uspto-grants-2012_08 |