2,2-Difluoro-4-phenylbutan-1-ol → 2,2-Difluoro-2-(m-tolyl)ethanol

반응식

[F:1][C:2]([F:15])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=1)[C:3](OCC)=[O:4].FC(F)(CCC1C=CC=CC=1)CO>>[F:1][C:2]([F:15])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=1)[CH2:3][OH:4]

참가 물질

반응물 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-ol

HCID 62394138Ethyl difluoro(3-methylphenyl)acetate

생성물 1

HCID 672459192,2-Difluoro-2-(m-tolyl)ethanol

실험 절차

Obtained from Intermediate 28 (9.5 g, 40 mmol) by the procedure described in Intermediate 2. The title compound was obtained (5.55 g, 80%) as oil.

출처 및 근거

ORD 기록: ord-2fb2a175e8de4ff5abdfd927db8f8cff
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08242177B2

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