2,2-Difluoro-2-(m-tolyl)ethanol → 1-{2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl}-3-methylbenzene

반응식

[F:1][C:2]([F:12])([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)[CH2:3][OH:4].[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]OCC(F)(F)CCC1C=CC=CC=1>>[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][O:4][CH2:3][C:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)([F:12])[F:1]

참가 물질

반응물 2

HCID 672459192,2-Difluoro-2-(m-tolyl)ethanol

HCID 67246468{4-((6-Bromohexyl)oxy]-3,3-difluorobutyl}benzene

생성물 1

HCID 672456761-{2-[(6-Bromohexyl)oxy]-1,1-difluoroethyl}-3-methylbenzene수율 100%

실험 절차

Obtained from Intermediate 29 (5.55 g, 32.2 mmol) by the procedure described in Intermediate 3. Purification by column chromatography with silica gel and n-hexane/ethyl acetate (from pure n-hexane to 10:1) as eluent gave the title compound (10.99 g, 100%) as oil.

후처리

customPurification by column chromatography with silica gel and n-hexane/ethyl acetate (from pure n-hexane to 10:1) as eluent

출처 및 근거

ORD 기록: ord-0a8068abfa23402595c424cb98fea254
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08242177B2

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