2-(3-Bromophenyl)-2,2-difluoroethanol → 1-Bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene

HRID 885547노트

반응식

HRID 885547 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([F:12])([F:11])[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]OCC(F)(F)CCC1C=CC=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:12])[CH2:9][O:10][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][Br:13])[CH:3]=1

참가 물질

3

반응물 2

HCID 672463332-(3-Bromophenyl)-2,2-difluoroethanolHCID 67246468{4-((6-Bromohexyl)oxy]-3,3-difluorobutyl}benzene

생성물 1

HCID 672452111-Bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene

실험 절차

Obtained from Intermediate 49 (17.6 g, 74 mmol) by the procedure described in Intermediate 3. The crude oil was purified by distillation to yield the title compound as oil of 60% of purity (9.5 g). The distillation residue was purified by column chromatography with silica gel and methylene chloride as eluent to yield a second batch of 1-bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene of 65% of purity (15.2 g) (overall yield: 53%).

후처리

  1. distillationThe crude oil was purified by distillation

출처 및 근거

ORD 기록
ord-f30c18b5f0e9438ea101a29d20588bd2
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242177B2

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