3-(2,2-Difluoro-2-phenylethoxy)propan-1-ol → 3-(2,2-Difluoro-2-phenylethoxy)propanal

HRID 885559노트

반응식

HRID 885559 반응식
[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH2:7][OH:8].C1(CCCCOCCC=O)C=CC=CC=1>>[F:1][C:2]([F:15])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][O:4][CH2:5][CH2:6][CH:7]=[O:8]

참가 물질

3

반응물 2

HCID 672459503-(2,2-Difluoro-2-phenylethoxy)propan-1-olHCID 866583073-(4-Phenylbutoxy)propionaldehyde

생성물 1

HCID 866583133-(2,2-Difluoro-2-phenylethoxy)propanal수율 60.3%

실험 절차

Obtained from Intermediate 81 (3.0 g, 14.4 mmol) by the procedure described in Intermediate 13. Purification by column chromatography with silica gel eluting with methylene chloride gave the title compound (1.86 g, 60%) as oil.

후처리

  1. customPurification by column chromatography with silica gel eluting with methylene chloride

출처 및 근거

ORD 기록
ord-f24f58ed7c6c49a7b7990d40c8be8014
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242177B2

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