2-Chloro-4-[2-(4-fluorophenyl)ethynyl]pyrimidine → 2-iso-Propylamino-4-[4-fluoro-phenylethynyl]pyrimidine
반응식
Cl[C:2]1[N:7]=[C:6]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[CH:4][N:3]=1>C(N)(C)C.O>[CH:6]([NH:7][C:2]1[N:7]=[C:6]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[CH:4][N:3]=1)([CH3:8])[CH3:5]참가 물질
4
실험 절차
A solution of 2-chloro-4-(4-fluoro-phenylethynyl)-pyrimidine (1 equiv.) in iso-propylamine (0.2 M) is heated at 35° C. for 24 h. The mixture is cooled to rt, diluted with water, and extracted with EtOAc. The organic layer is concentrated and the residue purified by column chromatography to provide the title compound.
후처리
- extractionextracted with EtOAc
- concentrationThe organic layer is concentrated
- customthe residue purified by column chromatography
출처 및 근거
- ORD 기록
- ord-f3ce1ddd55db4513a7ff0de63ea823ae
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08242273B2
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