Dichloromethane → (S)-tert-butyl 1-(4-(4-(2-chloro-3-(propylsulfonamido)phenyl)-2-cyclopropyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate

반응식

Br[C:2]1[N:3]=[C:4]([CH:33]2[CH2:35][CH2:34]2)[N:5]([CH2:25][O:26][CH2:27][CH2:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH:13][CH2:14][C@@H:15]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH3:16])[N:8]=1.[Cl:36][C:37]1[C:42](B2OC(C)(C)C(C)(C)O2)=[CH:41][CH:40]=[CH:39][C:38]=1[NH:52][S:53]([CH2:56][CH2:57][CH3:58])(=[O:55])=[O:54].C([O-])([O-])=O.[Na+].[Na+].C(Cl)Cl>COCCOC.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[Cl:36][C:37]1[C:38]([NH:52][S:53]([CH2:56][CH2:57][CH3:58])(=[O:55])=[O:54])=[CH:39][CH:40]=[CH:41][C:42]=1[C:2]1[N:3]=[C:4]([CH:33]2[CH2:35][CH2:34]2)[N:5]([CH2:25][O:26][CH2:27][CH2:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH:13][CH2:14][C@@H:15]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH3:16])[N:8]=1