1-Bromo-3-methoxypropane → 1-(3-Methoxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

HRID 885918노트

반응식

HRID 885918 반응식
[NH:1]1[CH:5]=[C:4]([B:6]2[O:14][C:11]([CH3:13])([CH3:12])[C:8]([CH3:10])([CH3:9])[O:7]2)[CH:3]=[N:2]1.Br[CH2:16][CH2:17][CH2:18][O:19][CH3:20]>>[CH3:20][O:19][CH2:18][CH2:17][CH2:16][N:2]1[CH:3]=[C:4]([B:6]2[O:7][C:8]([CH3:9])([CH3:10])[C:11]([CH3:13])([CH3:12])[O:14]2)[CH:5]=[N:1]1

참가 물질

3

반응물 2

HCID 5245511-Bromo-3-methoxypropaneHCID 27740104-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

생성물 1

HCID 671874231-(3-Methoxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

실험 절차

The title compound was prepared from pyrazole-4-boronic acid pinacol ester and 1-bromo-3-methoxypropane according to Method AC (90° C.) and was isolated as an orange gum (quantitative) that was used without further purification. LCMS (ES+) 267.0 (M+H)+, RT 2.96 minutes (Method 1).

후처리

  1. customwas isolated as an orange gum (quantitative) that
  2. customwas used without further purification
  3. customLCMS (ES+) 267.0 (M+H)+, RT 2.96 minutes (Method 1)

출처 및 근거

ORD 기록
ord-6ad4591ca0824b568b45864cdac3aa2f
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242116B2

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