1,1-Dimethoxyethyl(dimethyl)amine → HCID 178464914, 화합물

HRID 886044노트

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HRID 886044 반응식
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6]3[N:10]([CH2:11][CH2:12][O:13][C:4]=2[CH:3]=1)[CH:9]=[C:8]([C:14]([NH2:16])=[O:15])[N:7]=3.CO[C:21](OC)([N:23]([CH3:25])[CH3:24])[CH3:22]>C1(C)C=CC=CC=1>[CH3:24][N:23]([CH3:25])/[C:21](=[N:16]/[C:14]([C:8]1[N:7]=[C:6]2[N:10]([CH2:11][CH2:12][O:13][C:4]3[CH:3]=[C:2]([Br:1])[CH:18]=[CH:17][C:5]=32)[CH:9]=1)=[O:15])/[CH3:22]

참가 물질

4

반응물 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 582046299-Bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

생성물 1

HCID 178464914HCID 178464914, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
95 °C

실험 절차

To a solution of 8-Bromo-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulene-2-carboxylic acid amide (0.280 g, 0.000909 mol) in toluene (5 mL) was added dimethylacetamide-dimethylacetal (0.405 mL, 0.00273 mol). The solution was stirred at 95° C. for 4 h. The toluene was removed in vacuo to give 8-Bromo-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulene-2-carboxylic acid [1-dimethylamino-eth-(E)-ylidene]-amide. MS (ESI+) 377.1/379.1.

후처리

  1. customThe toluene was removed in vacuo

출처 및 근거

ORD 기록
ord-ecddb76815bf44f5a3b9eab28475861d
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242104B2

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