2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol → 1,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-

HRID 886695노트

반응식

HRID 886695 반응식
[F:1][C:2]([F:17])([F:16])[C:3]([CH2:7][NH:8]CC1C=CC=CC=1)([OH:6])[CH2:4][OH:5]>C(O)C.[OH-].[OH-].[Pd+2]>[NH2:8][CH2:7][C:3]([OH:6])([C:2]([F:17])([F:16])[F:1])[CH2:4][OH:5]

참가 물질

4

반응물 1

HCID 248097812-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol

생성물 1

HCID 248097501,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-수율 95.2%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

A solution of 3,3,3-trifluoro-2-{[(phenylmethyl)amino]methyl}-1,2-propanediol (8.33 g, 33.4 mmol) in ethanol (550 ml) containing palladium hydroxide on carbon (20%, 800 mg) was stirred under an atmosphere of hydrogen for 24 hours. The catalyst was filtered off via a pad of celite and the filtrate was concentrated under reduced pressure, toluene was added and the solution evaporated again under reduced pressure to give the title compound (5.06 g) as an oil.

후처리

  1. filtrationThe catalyst was filtered off via a pad of celite
  2. concentrationthe filtrate was concentrated under reduced pressure, toluene
  3. additionwas added
  4. customthe solution evaporated again under reduced pressure

출처 및 근거

ORD 기록
ord-c42b2b1722744161942cd27dc0535e31
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247377B2

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