4-Chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine → 2-(Methylsulfonyl)thieno[2,3-d]pyrimidine
반응식
Cl[C:2]1[C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[N:7]=1>C(O)C>[CH3:11][S:8]([C:6]1[N:7]=[CH:2][C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=1)(=[O:9])=[O:10]참가 물질
3
실험 절차
To 500 mL round-bottom flask was added 4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine (15 g, 60 mmol), ethyl alcohol (300 mL), nitrogen gas was bubbled for 5 minutes. To this solution was added 10% palladium on activated charcoal (15 g). To the resulting mixture was bubbled hydrogen gas over night. The reaction mixture was filtered through Celite. The filtrate was concentrated to give the title compound (11.0 g). MS (ES+): 215 (M+H)+.
후처리
- customwas bubbled for 5 minutes
- additionTo this solution was added 10% palladium on activated charcoal (15 g)
- customTo the resulting mixture was bubbled hydrogen gas over night
- filtrationThe reaction mixture was filtered through Celite
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-557104fe24e6488981a98533190e5ff9
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08247409B2
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