Ethylamine → N-Ethyl-6-methyl-2-(methylsulfanyl)pyrimidin-4-amine
반응식
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.[CH2:11]([NH2:13])[CH3:12]>O>[CH2:11]([NH:13][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1)[CH3:12]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To the 4-chloro-6-methyl-2-(methylthio)pyrimidine from above was added 30 mL of a solution of 70% ethylamine in water. The reaction mixture was heated to 50° C. for 3 h. After completion, excess ethylamine was evaporated on rotary evaporator under vacuum. The solid was filtered and dried under vacuum to afford N-ethyl-6-methyl-2-(methylthio)pyrimidin-4-amine (20 g, 90% yield).
후처리
- customAfter completion, excess ethylamine was evaporated on rotary evaporator under vacuum
- filtrationThe solid was filtered
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-57504d35e3c04fd19a960d8fee9c70e8
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08247408B2
반응 노트
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