Hydrogen chloride-ethyl acetate → HCID 68580287, 화합물

반응식

[N:1]1([C:7]2[CH:24]=[CH:23][C:10]3[CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH2:14][O:15][C:9]=3[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:31]>>[ClH:31].[N:1]1([C:7]2[CH:24]=[CH:23][C:10]3[CH2:11][NH:12][CH2:13][CH2:14][O:15][C:9]=3[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetate

HCID 68578482tert-butyl 8-(morpholin-4-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

생성물 1

HCID 68580287HCID 68580287, 화합물수율 54.5%

실험 절차

A solution of tert-butyl 8-(morpholin-4-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (50.0 mg, 0.150 mmol) in 4N hydrogen chloride-ethyl acetate (1 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (25.0 mg, 54.5%) as a solid.

후처리

customthe solvent was evaporated under reduced pressure
customThe residue was recrystallized from a mixed solvent of methanol and ether

출처 및 근거

ORD 기록: ord-2ef6f2e284714782aecb95e0674e9d8d
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08247403B2

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