Hydrogen chloride-ethyl acetate → HCID 68578489, 화합물

반응식

[N:1]1([C:6]2[CH:23]=[CH:22][C:9]3[CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH2:13][O:14][C:8]=3[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:30]>>[ClH:30].[ClH:30].[N:1]1([C:6]2[CH:23]=[CH:22][C:9]3[CH2:10][NH:11][CH2:12][CH2:13][O:14][C:8]=3[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetate

HCID 68579876HCID 68579876, 화합물

생성물 1

HCID 68578489HCID 68578489, 화합물수율 73.3%

실험 절차

A solution of tert-butyl 8-(pyrrolidin-1-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (110 mg, 0.345 mmol) in 4N hydrogen chloride-ethyl acetate (2 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (74.0 mg, 73.3%) as a solid.

후처리

customthe solvent was evaporated under reduced pressure
customThe residue was recrystallized from a mixed solvent of methanol and ether

출처 및 근거

ORD 기록: ord-baee1012e92146398ed810ea4203af52
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08247403B2

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