Hydrogen chloride-ethyl acetate → HCID 68578005, 화합물

반응식

[CH2:1]([N:3]([CH2:22][CH3:23])[C:4]1[CH:21]=[CH:20][C:7]2[CH2:8][N:9](C(OC(C)(C)C)=O)[CH2:10][CH2:11][O:12][C:6]=2[CH:5]=1)[CH3:2].C(OCC)(=O)C.[ClH:30]>>[ClH:30].[ClH:30].[CH2:22]([N:3]([CH2:1][CH3:2])[C:4]1[CH:21]=[CH:20][C:7]2[CH2:8][NH:9][CH2:10][CH2:11][O:12][C:6]=2[CH:5]=1)[CH3:23]

참가 물질

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetate

HCID 68578546HCID 68578546, 화합물

생성물 1

HCID 68578005HCID 68578005, 화합물수율 62.9%

실험 절차

A solution of tert-butyl 8-(diethylamino)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (250 mg, 0.780 mmol) in 4N hydrogen chloride-ethyl acetate (6 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (144 mg, 62.9%) as a solid.

후처리

customthe solvent was evaporated under reduced pressure
customThe residue was recrystallized from a mixed solvent of methanol and ether

출처 및 근거

ORD 기록: ord-e6bd917b94e44c24859fb7c3ba64308d
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08247403B2

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