Boron tribromide → 5-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one

반응식

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[N:13][N:12]([CH3:15])[C:11](=[O:16])[CH:10]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[N:13][N:12]([CH3:15])[C:11](=[O:16])[CH:10]=2)=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 25134Boron tribromide

HCID 569461985-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one

생성물 1

HCID 569461995-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one

실험 절차

5-(4-Hydroxyphenyl)-2-methyl-2H-pyridazin-3-one was prepared from 5-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one with BBr3 using the procedure described in Example 86 Step 2; Mp 296-8° C.; MS m/z 203 (M+H).

출처 및 근거

ORD 기록: ord-07a9c73f413a4dc2a95cbe8bef9c7681
출처 데이터셋: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08247414B2

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