1-Piperazinebutanoic acid, 4-(2-methoxyphenyl)- → (2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl)methyl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate

HRID 887073

반응식

HRID 887073 반응식
[OH:1][CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][CH2:30][C:31](O)=[O:32])[CH2:24][CH2:23]1>>[CH3:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[CH2:23][CH2:24][N:25]([CH2:28][CH2:29][CH2:30][C:31]([O:1][CH2:2][C:3]2[CH:12]=[C:11]3[C:6]([CH2:7][CH2:8][C:9](=[O:13])[NH:10]3)=[CH:5][CH:4]=2)=[O:32])[CH2:26][CH2:27]1

참가 물질

3

반응물 2

HCID 113119811-Piperazinebutanoic acid, 4-(2-methoxyphenyl)-HCID 533933487-(Hydroxymethyl)-3,4-dihydroquinolin-2(1H)-one

생성물 1

HCID 57420191(2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl)methyl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate

실험 절차

(2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl)methyl 4-(4-(2-methoxyphenyl)piperazin-1-yl)butanoate (38c) (Scheme 7) was prepared from the carbinol 37 and the carboxylic acid 18c according to the protocol described for the compound 38a (Example 55). Colorless oil, 0.15 g (41%). 1H NMR (400 MHz, CDCl3): δ 1.84 (quintet, J=7.2 Hz, 2H); 2.38-2.54 (m, 4H); 2.58-2.60 (m, 6H); 2.95 (t, J=8.4 Hz, 2H); 3.03 (broad s, 4H); 3.80 (s, 3H); 5.02 (s, 2H); 6.80-6.94 (m, 4H); 7.09 (d, J=7.6 Hz, 1H); 9.30 (m, 1H). MS (ESI): m/z=438.20 (M+H+).

출처 및 근거

ORD 기록
ord-d70c4ef7430a42ad9495f2cc0ab63a89
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247420B2

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