Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-Indazol-4-amine, 1-methyl- → N-[3-fluoro-4-(1-piperidinyl)benzyl]-N'-(1-methyl-1H-indazol-4-yl)urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-Indazol-4-amine, 1-methyl- | HCID 153838 | — |
| 반응물 | NoName_3327 | HCID 413085 | — |
| 반응물 | 1-[2-Fluoro-4-(isocyanatomethyl)phenyl]piperidine | HCID 22337607 | — |
| 생성물 | N-[3-fluoro-4-(1-piperidinyl)benzyl]-N'-(1-methyl-1H-indazol-4-yl)urea | HCID 22337698 | — |
반응 단계
The title compound was prepared using the procedure described in Example 89B using 1-[2-fluoro-4-(isocyanatomethyl)phenyl]piperidine and 1-methyl-1H-indazol-4-amine instead of 1-bromo-4-(isocyanatomethyl)benzene and the product from Example 89A. NMR (DMSO-d6) δ 9.19 (s, 1H), 8.22 (s, 1H), 7.25 (m, 4H), 7.18 (d, 2H), 4.31 (s, 2H), 4.00 (s, 3H), 3.15 (m, 4H), 1.77 (m, 4H), 1.66 (m, 2H); MS (ESI) (M+H)+ 382.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08247413B2 |
| 출처 데이터셋 | uspto-grants-2012_08 |
| ORD ID | ord-2eccea5bad1c41208f788736010dd5f2 |
| 출처 메모 | uspto-grants-2012_08 |