Trifluoroacetic acid → 4-(Aminomethyl)benzonitrile

HRID 887261

반응식

HRID 887261 반응식
C(OC([N:8]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=1)C(OC(C)(C)C)=O)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:24][CH2:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]#[N:8])=[CH:18][CH:19]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 3683768Tert-butyl N-[(4-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

생성물 1

HCID 826084-(Aminomethyl)benzonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of N,N-bis(tert-butoxycarbonyl)-4-cyanobenzylamine (0.75 g, 2.25 mmol, prepared according to the literature described in Synthetic Communications 4419:28 (1998), in CH2Cl2 (15 mL) was treated with trifluoroacetic acid (8 mL). After stirring at room temperature for 3 hours, the mixture was concentrated under reduced pressure and the residue was azeotroped with diethyl ether.

후처리

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customthe residue was azeotroped with diethyl ether

출처 및 근거

ORD 기록
ord-25d9167931af4b95b23a56ba7ae42a65
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247413B2

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