Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosgene → 3-Chloro-5-isocyanatoisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | 3-Chloroisoquinolin-5-amine | HCID 16749040 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 3-Chloro-5-isocyanatoisoquinoline | HCID 22337685 | — |
반응 단계
5-Amino-3-chloroisoquinoline (740 mg, 4.15 mmol) was suspended in toluene (20 mL) and treated with 20% w/v phosgene solution in toluene (9 mL) and triethylamine (5 mL). The mixture was refluxed overnight and was then concentrated in vacuo and used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08247413B2 |
| 출처 데이터셋 | uspto-grants-2012_08 |
| ORD ID | ord-6c33b8c267a94638be4665ad47409470 |
| 출처 메모 | uspto-grants-2012_08 |