2,4-Dimethylbenzylamine → N-(2,4-dimethylbenzyl)-2-(5-isoquinolinyl)propanamide

참여 물질

역할	이름	HCID	투입량
반응물	2,4-Dimethylbenzylamine	HCID 66761	—
반응물	2-(Isoquinolin-5-YL)acetic acid	HCID 12018708	—
반응물	2-(Isoquinolin-5-yl)propanoic acid	HCID 22337638	—
생성물	N-(2,4-dimethylbenzyl)-2-(5-isoquinolinyl)propanamide	HCID 10426039	—

반응 단계

The title compound was prepared using the procedure described in Example 222B using 2,4-dimethylbenzylamine and 2-(5-isoquinolinyl)propanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 319 (M+H)+; MS (ESI−) m/z 317 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 1.52 (d, J 7.1, 3H), 2.13 (s, 3H), 2.21 (s, 3H), 4.20 (m, 2H), 4.51 (q, J 7.1, 1H), 6.88 (d, J 7.5, 1H), 6.94 (s, 1H), 6.98 (d, J 7.5, 1H), 7.82 (t, J 7.8, 1H), 7.99 (d, J 6.5, 1H), 8.21 (d, J 8.1, 1H), 8.35 (d, J 6.4, 1H), 8.44 (t, J 5.8, 1H), 8.62 (d, J 6.2, 1H), 9.57 (s, 1H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08247413B2
출처 데이터셋	uspto-grants-2012_08
ORD ID	ord-f624c8b060604160968a06fd040e9866
출처 메모	uspto-grants-2012_08