참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | 4-Fluorobenzene-1,2-diamine | HCID 164584 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-Fluorobenzimidazole | HCID 235698 | — |
반응 단계
To the solution of 4-fluoro-benzene-1,2-diamine (10 g, 79.4 mmol) and triethylorthoformate (117 mL, 793 mmol) was added few drop of ethanol and the reaction mixture was refluxed at 150° C. overnight. The reaction mixture was concentrated and the residue was directly taken to the next step. [M+H]=137.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08247418B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_08 |
|---|
| ORD ID | ord-55385f5e23674ed5a2bf3443147fd061 |
|---|
| 출처 메모 | uspto-grants-2012_08 |
|---|
