Potassium Phosphate, Tribasic → (1H-benzo[d]imidazol-2-yl)(4-(3-(2-(trifluoromethyl)pyridin-4-yl)pyrazin-2-yloxy)phenyl)methanone

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Phosphate, Tribasic	HCID 62657	—
반응물	2-(Trifluoromethyl)pyridine-4-boronic acid	HCID 45158880	—
반응물	(4-(3-chloropyrazin-2-yloxy)phenyl)(1H-benzo[d]imidazol-2-yl)methanone	HCID 46207940	—
용매	1,2-Dimethoxyethane	HCID 8071	—
생성물	(1H-benzo[d]imidazol-2-yl)(4-(3-(2-(trifluoromethyl)pyridin-4-yl)pyrazin-2-yloxy)phenyl)methanone	HCID 46207696	—

반응 조건

온도	80 °C

반응 단계

A mixture of (1H-benzo[d]imidazol-2-yl)(4-(3-chloropyrazin-2-yloxy)phenyl)methanone (300 mg, 0.855 mmol), potassium phosphate (545 mg, 2.57 mmol), 2-(trifluoromethyl)pyridin-4-ylboronic acid (490 mg, 2.57 mmol), and Bis-[4-(di-tert-butylphosphino)-N,N-dimethylbenzenamine]palladium dichloride (121 mg, 0.171 mmol) in dimethoxyethane was heated to 80° C. Following complete reaction, the mixture was cooled to room temperature which caused a solid to precipitate which was collected by filtration and dried to give (1H-benzo[d]imidazol-2-yl)(4-(3-(2-(trifluoromethyl)pyridin-4-yl)pyrazin-2-yloxy)phenyl)methanone. MS (ESI, pos. ion) m/z: 461.0 (M+1). IC50 (uM) +++++.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08247418B2
출처 데이터셋	uspto-grants-2012_08
ORD ID	ord-f26ae8bb5db84a4a9d9beb239c9e9bb0
출처 메모	uspto-grants-2012_08