2,4-Difluorophenylboronic acid → [1-(2,4-difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine

반응식

[Cl:1][c:2]1[n:3][c:4]([NH:14][c:15]2[n:16][nH:17][c:18]([CH3:20])[cH:19]2)[cH:5][c:6]2[cH:7][c:8]([O:12][CH3:13])[cH:9][cH:10][c:11]12.[F:21][c:22]1[c:23]([B:29]([OH:30])[OH:31])[cH:24][cH:25][c:26]([F:28])[cH:27]1>>[c:2]1(-[c:23]2[c:22]([F:21])[cH:27][c:26]([F:28])[cH:25][cH:24]2)[n:3][c:4]([NH:14][c:15]2[n:16][nH:17][c:18]([CH3:20])[cH:19]2)[cH:5][c:6]2[cH:7][c:8]([O:12][CH3:13])[cH:9][cH:10][c:11]12

참가 물질

반응물 2

HCID 27343342,4-Difluorophenylboronic acid

HCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

생성물 1

HCID 23633788[1-(2,4-difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine

출처 및 근거

ORD 기록: ord-8e499c7957754803b62b2ffde344ad61
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

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