Triethylamine → N-(6-bromo-2-pyridinyl)-3-methylbut-2-enamide

HRID 887597

반응식

HRID 887597 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.CCN(CC)CC.[CH3:16][C:17]([CH3:22])=[CH:18][C:19](Cl)=[O:20]>C(Cl)Cl>[Br:8][C:4]1[N:3]=[C:2]([NH:1][C:19](=[O:20])[CH:18]=[C:17]([CH3:22])[CH3:16])[CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1023943-Methyl-2-butenoyl chlorideHCID 3008092-Amino-6-bromopyridine

생성물 1

HCID 43520526N-(6-bromo-2-pyridinyl)-3-methylbut-2-enamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-amino-6-bromopyridine (3.015 g, 0.017 mol) and Et3N (2.40 mL, 0.017 mol) in CH2Cl2 (20.0 mL), was added 3,3-dimethylacryloylchloride (1.96 mL, 0.017 mol) under N2 at 0° C. The mixture was slowly warmed to RT and stirred for 12 h. The reaction was quenched by the addition of H2O (20.0 mL), the organic layer was separated, dried over Na2SO4 and evaporated to dryness to yield crude compound which was used without purification.

후처리

  1. customThe reaction was quenched by the addition of H2O (20.0 mL)
  2. customthe organic layer was separated
  3. dry with materialdried over Na2SO4
  4. customevaporated to dryness
  5. customto yield crude compound which
  6. customwas used without purification

출처 및 근거

ORD 기록
ord-075960414edf481099c04b6dcf2897ff
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247430B2

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