Ethanol, reaction products with ammonia, distn. residues → 2-(2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)ethanamine

HRID 887764노트

반응식

HRID 887764 반응식
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][C:7]3[CH2:13][CH2:12][C:11](=[CH:14][C:15]#[N:16])[C:8]=32)=[N:3]1.N.C(O)C>C(O)C.[Co]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][C:7]3[CH2:13][CH2:12][C:11](=[CH:14][CH2:15][NH2:16])[C:8]=32)=[N:3]1

참가 물질

5

반응물 2

HCID 22020343Ethanol, reaction products with ammonia, distn. residuesHCID 68699579(2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)acetonitrile

생성물 1

HCID 686989692-(2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)ethanamine수율 100.3%

시약·촉매·용매 2

HCID 104730Cobalt촉매HCID 702Ethanol용매

실험 절차

To a solution of (2-methyl-6,7-dihydrocyclopenta[e]indazol-8(2H)-ylidene)acetonitrile (600 mg, 2.87 mmol) in ethanol (14 mL) were added Raney cobalt (6 g) and 2M ammonia/ethanol solution (14 mL), and the mixture was stirred under a hydrogen atmosphere at room temperature for 3 hr. The catalyst was filtered off through celite, and the filtrate was concentrated under reduced pressure to give the title compound (614 mg, yield 99%).

후처리

  1. filtrationThe catalyst was filtered off through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5b2f92781b614cb98c0dd3b6eafc81ce
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247429B2

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