Methyl 5-fluoro-2-methyl-3-nitrobenzoate → Methyl 3-amino-5-fluoro-2-methylbenzoate
반응식
[F:1][C:2]1[CH:3]=[C:4]([N+:13]([O-])=O)[C:5]([CH3:12])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]>CO.[C].[Pd]>[NH2:13][C:4]1[C:5]([CH3:12])=[C:6]([CH:11]=[C:2]([F:1])[CH:3]=1)[C:7]([O:9][CH3:10])=[O:8]참가 물질
4
실험 절차
To a solution of methyl 5-fluoro-2-methyl-3-nitrobenzoate (3.20 g, 15.0 mmol) in methanol (150 mL) was added palladium-carbon powder (320 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 4 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (1.47 g, yield 54%).
후처리
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-8d9bcf6d6c454a35a601fdf96a745dbd
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08247429B2
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