Nitric Acid → N-(4-Methoxy-2-methyl-5-nitrophenyl)acetamide

HRID 887902

반응식

HRID 887902 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([CH3:13])[CH:4]=1.[N+:14]([O-])([OH:16])=[O:15]>C(O)(=O)C>[CH3:1][O:2][C:3]1[C:8]([N+:14]([O-:16])=[O:15])=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([CH3:13])[CH:4]=1

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 95082N-(4-Methoxy-2-methylphenyl)-acetamide

생성물 1

HCID 21260362N-(4-Methoxy-2-methyl-5-nitrophenyl)acetamide수율 53%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

34 g (0.19 mol) of N-(4-methoxy-2-methylphenyl)acetamide were added in small portions to a mixture of 40 ml of glacial acetic acid and 70 ml of fuming nitric acid at −10 to −15° C. These portions were such that the temperature did not rise above −10° C. The reaction mixture was then poured onto ice. The resulting precipitate was filtered off with suction and washed with water, ethanol and diethyl ether. 22.5 g (53%) of the desired product were obtained.

후처리

  1. customdid not rise above −10° C
  2. additionThe reaction mixture was then poured onto ice
  3. filtrationThe resulting precipitate was filtered off with suction
  4. washwashed with water, ethanol and diethyl ether

출처 및 근거

ORD 기록
ord-8a55bd1ad4a5448491ddf9038b7f3a33
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247452B2

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