Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 4-Formylbenzoate → 4-[3-[1,3]-Dioxolan-2-yl-propenyl)benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 4-Formylbenzoate | HCID 15294 | — |
| 반응물 | [1-(1,3-Dioxan-2-yl)ethyl]triphenylphosphoniumbromide | HCID 22107466 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[3-[1,3]-Dioxolan-2-yl-propenyl)benzoic acid methyl ester | HCID 86752164 | 50.3% |
반응 단계
The olefin was prepared from 4.3 g (26.2 mmol) of the aldehyde 167, 13.94 g of [1-(1,3-dioxan-2-yl)ethyl]triphenylphosphoniumbromide and 12.6 mL (32.0 mmol) of n-BuLi in 75 mL of THF as described for the synthesis of 156 in Example 8. Flash chromatography (elution with 10% ethyl acetate in hexane) gave 3.27 g of the olefin 168. 1H NMR consistent with the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723459 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-6120ae4e516c4335a3f2eb3671f18da1 |
| 출처 메모 | uspto-grants-1998_03 |