Hydroxylamine → tert-butyl 4-(N-hydroxyamidino)-piperazine-1-carboxylate
반응식
[C:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1)#[N:2].[NH2:16][OH:17]>C(O)C>[OH:17][NH:16][C:1](=[NH:2])[N:3]1[CH2:4][CH2:5][N:6]([C:9]([O:11][C:12]([CH3:14])([CH3:13])[CH3:15])=[O:10])[CH2:7][CH2:8]1참가 물질
4
실험 절차
To a solution of tert-butyl 4-cyanopiperazine-1-carboxylate (15 g, 76 mmol) in ethanol (150 mL) was added hydroxylamine (50% aqueous solution, 6.2 mL, 92 mmol) and the reaction mixture was stirred at RT for 6 hours. The solvent was evaporated under vacuum and the solid obtained was triturated with hexane (100 mL) and filtered to obtain 15 g (80%) of the title compound as a solid. TLC-Chloroform/methanol (9/1): Rf=0.15.
후처리
- customThe solvent was evaporated under vacuum
- customthe solid obtained
- customwas triturated with hexane (100 mL)
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-ec7ddd5bec6f4099bb5f3dc07cecc918
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08247437B2
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