1-Chloro-4-(trifluoromethylsulfonyl)benzene → (3R)-3-methyl-1-{4-[(trifluoromethyl)sulfonyl]phenyl}piperazine

HRID 888197

반응식

HRID 888197 반응식
[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4](C2C=CC(S(C)(=O)=O)=CC=2)[CH2:3]1.Cl[C:19]1[CH:24]=[CH:23][C:22]([S:25]([C:28]([F:31])([F:30])[F:29])(=[O:27])=[O:26])=[CH:21][CH:20]=1>>[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:19]2[CH:24]=[CH:23][C:22]([S:25]([C:28]([F:31])([F:30])[F:29])(=[O:27])=[O:26])=[CH:21][CH:20]=2)[CH2:3]1

참가 물질

3

반응물 2

HCID 7033241-Chloro-4-(trifluoromethylsulfonyl)benzeneHCID 26597658(3R)-1-[4-(Methanesulfonyl)phenyl]-3-methylpiperazine

생성물 1

HCID 11580385(3R)-3-methyl-1-{4-[(trifluoromethyl)sulfonyl]phenyl}piperazine

실험 절차

The title compound was prepared following the procedure of Intermediate 26, but starting from 1-chloro-4-(trifluoromethanesulfonyl)benzene. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a pale yellow solid. M+(ESI): 309.2. HPLC (Condition A), Rt: 2.3 min (HPLC purity: 99.5%).

후처리

  1. customThe title compound was prepared
  2. customPurification by flash chromatography (CHCl3/MeOH)

출처 및 근거

ORD 기록
ord-5485a5529022424594df9722d0f7b390
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247437B2

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