참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hexane | HCID 8058 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | ((2-Chloroethyl)thio)benzene | HCID 21702 | — |
| 반응물 | HCID 178526679 | HCID 178526679 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Nitro-2-(2-phenylsulfanyl-ethylsulfanyl)pyridine | HCID 67134239 | 66% |
반응 단계
3.44 g (20.0 mmol) (2-chloroethyl)(phenyl)sulfane and 5.53 g (40.0 mmol) potassium carbonate were added to a solution of 1.56 g (10.0 mmol) 2-mercapto-3-nitropyridine in DMF (30 ml) and heated for 4 h at 60° C. Then the mixture was diluted with EE and washed with brine. The organic phase was separated off, dried over Na2SO4, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 9:1) of the residue yielded 1.93 g (6.6 mmol, 66%) 3-nitro-2-(2-phenylsulfanyl-ethylsulfanyl)pyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08247573B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_08 |
|---|
| ORD ID | ord-d3e7cedc03e24bf9af5227f9c7d87216 |
|---|
| 출처 메모 | uspto-grants-2012_08 |
|---|
