Trifluoroacetic acid → Trifluoroacetic acid

HRID 888380노트

반응식

HRID 888380 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([C:21]([O:23][CH3:24])=[O:22])[CH:11]=[C:12]([CH:20]=2)[C:13]([O:15]C(C)(C)C)=[O:14])=[N:6][CH:7]=1.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>ClCCl>[C:27]([OH:29])([C:26]([F:31])([F:30])[F:25])=[O:28].[CH3:24][O:23][C:21]([C:10]1[CH:11]=[C:12]([CH:20]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=2)[CH:9]=1)[C:13]([OH:15])=[O:14])=[O:22]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 68499855tert-Butyl methyl 5-(5-methylpyridin-2-yl)isophthalate

생성물 2

HCID 6422Trifluoroacetic acidHCID 684994173-(Methoxycarbonyl)-5-(5-methylpyridin-2-yl)benzoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl methyl 5-(5-methylpyridin-2-yl)isophthalate in dichloromethane (75 mL) was added 25 mL of trifluoroacetic acid. After 16 h, the reaction was concentrated and dried under vacuum to give TFA salt of the title compound (6.5 g). MS 272.1 (M+1).

후처리

  1. concentrationthe reaction was concentrated
  2. customdried under vacuum

출처 및 근거

ORD 기록
ord-ea1ada1909f640bc8d7b2de2c47a53ca
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247401B2

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