홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Dichloromethane → Methyl 3-(5-methylpyridin-2-yl)-5-(1-methyl-1H-1,2,3-triazol-5-yl)benzoate

HRID 888387
노트
인쇄 미리보기

반응식

HRID 888387 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[C:16]([C:18]3[N:22]([CH2:23][Si](C)(C)C)[N:21]=[N:20][CH:19]=3)[CH:17]=2)[C:11]([O:13][CH3:14])=[O:12])=[N:6][CH:7]=1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.ClCCl.[Cl-].[NH4+]>C1COCC1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[C:16]([C:18]3[N:22]([CH3:23])[N:21]=[N:20][CH:19]=3)[CH:17]=2)[C:11]([O:13][CH3:14])=[O:12])=[N:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 25517Ammonium ChlorideHCID 2724141Tetrabutylammonium FluorideHCID 68496792Methyl 3-(5-methylpyridin-2-yl)-5-(1-((trimethylsilyl)methyl)-1H-1,2,3-triazol-5-yl)benzoate

생성물 1

HCID 68500364Methyl 3-(5-methylpyridin-2-yl)-5-(1-methyl-1H-1,2,3-triazol-5-yl)benzoate수율 85.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of methyl 3-(5-methylpyridin-2-yl)-5-{1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-5-yl}benzoate (122 mg, 0.321 mmol) in THF (5 mL) was added 2 M tetrabutylammonium fluoride in THF (1.60 mL, 3.20 mmol). After 16 h, the mixture was distributed between 100 ml of dichloromethane and 100 ml of 1 M ammonium chloride solution. The organic layer was washed with 50 mL of brine and concentrated to give title compound (85 mg). MS 309.1 (M+1).

후처리

  1. washThe organic layer was washed with 50 mL of brine
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-016d9e0aaec04c69b4485ac15310600f
출처 데이터셋
uspto-grants-2012_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08247401B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트