Ethanol → (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

HRID 888508노트

반응식

HRID 888508 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:19][C:20]([OH:22])=[O:21])[CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:28][CH2:29]O>>[CH2:28]([O:21][C:20](=[O:22])[CH2:19][C:11]1[CH:12]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1)[CH3:29]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 59644613(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid

생성물 1

HCID 58148866(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

실험 절차

To (3-benzyloxy-5-trifluoromethyl-phenyl)-acetic acid (1.5 g, 5.4 mmol) in EtOH (30 mL) was added sulfuric acid (1 mL), and the mixture was stirred overnight at room temperature. Once no starting material was seen by analytical LCMS, the reaction was worked up to give (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester.

출처 및 근거

ORD 기록
ord-dfa3e7d3392747069729aee290d85469
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08247602B2

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