2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 2-Chloro-4-[2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazol-4-ylethynyl]-pyridine

HRID 8886노트

반응식

HRID 8886 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[CH:4][N:3]=1.I[C:15]1[N:16]=[C:17]([CH3:25])[N:18]([CH2:20][C:21]([F:24])([F:23])[F:22])[CH:19]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:15]2[N:16]=[C:17]([CH3:25])[N:18]([CH2:20][C:21]([F:23])([F:24])[F:22])[CH:19]=2)[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 219853912-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridineHCID 219853984-Iodo-2-methyl-1-(2,2,2-trifluoroethyl)-1H-imidazole

생성물 1

HCID 114720912-Chloro-4-[2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazol-4-ylethynyl]-pyridine

실험 절차

The title compound, MS: m/e=300.0 (M+H+), was prepared in accordance with the general method of example A, step 2, from 2-chloro-4-trimethylsilanylethynyl-pyridine and 4-iodo-2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazole.

출처 및 근거

ORD 기록
ord-5c00e3d49dd94ec4bbdbd013597f9057
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091222B2

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