2-Bromoanthraquinone → 2-Bromo-9,10-diphenyl-9,10-dihydroanthracene-9,10-diol

HRID 888683

반응식

HRID 888683 반응식
[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[C:12](=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[O:17])[C:4]=2[CH:3]=1.[C:18]1([Li])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>O1CCCC1>[Br:1][C:2]1[CH:15]=[CH:14][C:13]2[C:12]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)([OH:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([C:2]3[CH:15]=[CH:14][CH:13]=[CH:4][CH:3]=3)([OH:17])[C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 2210132-BromoanthraquinoneHCID 178506676HCID 178506676, 화합물

생성물 1

HCID 231602182-Bromo-9,10-diphenyl-9,10-dihydroanthracene-9,10-diol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4.9 g (17 mmol) of 2-bromo-9,10-anthraquinone was put in a 300 mL three-neck flask, the atmosphere in the flask was substituted by nitrogen, and 100 mL of tetrahydrofuran (THF) was added thereto and dissolved well. Then, 18 mL (37 mmol) of phenyllithium was dropped into this solution and stirred at room temperature for approximately 12 hours. After reaction, the solution was washed with water, and an aqueous layer was extracted with ethyl acetate. The extracted solution and an organic layer were dried with magnesium sulfate. After drying, the mixture was subjected to suction filtration, and the filtrate was concentrated, so that 2-bromo-9,10-diphenyl-9,10-dihydroanthracene-9,10-diol (about 7.6 g), which was the object of the synthesis, was obtained.

후처리

  1. additionwas added
  2. dissolutiondissolved well
  3. customAfter reaction
  4. washthe solution was washed with water
  5. extractionan aqueous layer was extracted with ethyl acetate
  6. dry with materialThe extracted solution and an organic layer were dried with magnesium sulfate
  7. customAfter drying
  8. filtrationthe mixture was subjected to suction filtration
  9. concentrationthe filtrate was concentrated, so that 2-bromo-9,10-diphenyl-9,10-dihydroanthracene-9,10-diol (about 7.6 g), which
  10. customthe object of the synthesis
  11. customwas obtained

출처 및 근거

ORD 기록
ord-b365f05febbb4a008e8cd26da89c3571
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08251765B2

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