Benzyl formate → HCID 86609779, 화합물

HRID 888697

반응식

HRID 888697 반응식
[CH2:1]([O:8][C:9]([C:11]1[CH:23]=[CH:22][C:21]2[C:20]3[C:15](=[CH:16][C:17]([C:24]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[O:25])=[CH:18][CH:19]=3)[CH2:14][C:13]=2[CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:34](OCC1C=CC=CC=1)=[O:35].CC(C)([O-])C.[K+]>C1COCC1>[CH2:27]([O:26][C:24]([C:17]1[CH:18]=[CH:19][C:20]2[C:21]3[C:13](=[CH:12][C:11]([C:9]([O:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[O:10])=[CH:23][CH:22]=3)[CH:14]([CH:34]=[O:35])[C:15]=2[CH:16]=1)=[O:25])[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

참가 물질

5

반응물 3

HCID 7708Benzyl formateHCID 23665647Potassium tert-butoxideHCID 66910038Dibenzyl 9H-fluorene-2,7-dicarboxylate

생성물 1

HCID 86609779HCID 86609779, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In a dry argon-purged flask, 2,7-fluorenedicarboxylic acid dibenzyl ester (3.0 g, 0.0065 mol) was dissolved in anh. THF (60 mL) at room temperature. Benzyl formate (4.2 mL, 0.035 mol, stored over anhydrous K2CO3) was added followed by addition of potassium tert-butoxide 95% (2.7 g, 0.023 mol). The reaction was stirred for three hours then the reaction was quenched with the addition of water and acidified with HCl to pH 2. The organic solvent was partially evaporated at reduced pressure. The product was twice extracted with ethyl acetate (600 mL then 200 mL). The combined organic layers were washed three times with brine, dried over sodium sulfate, filtered and evaporated to dryness. The crude product was washed with hexanes and methanol (1.9 g, 60%). 1H-NMR (d6-DMSO): δ (ppm) 11.9 (s, ˜1H, formyl); 8.8 (s, 1H, Ar); 8.5 (s, 1H, Ar); 8.4 (s, 1H, Ar); 8.2 (m, 2H, Ar); 7.9 (m, 2H, Ar); 7.5-7.4 (m, 10H, Bz); 5.4 (s, 4H, Ar).

후처리

  1. customIn a dry argon-purged flask
  2. customthe reaction was quenched with the addition of water
  3. customThe organic solvent was partially evaporated at reduced pressure
  4. extractionThe product was twice extracted with ethyl acetate (600 mL
  5. washThe combined organic layers were washed three times with brine
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated to dryness
  9. washThe crude product was washed with hexanes and methanol (1.9 g, 60%)

출처 및 근거

ORD 기록
ord-77a739a595a2433d8ab7232b73530fc6
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252275B2

연결된 노트

불러오는 중…