Water → 1-Bromo-2-(methoxymethyl)benzene

HRID 888713

반응식

HRID 888713 반응식
[CH3:1][O-:2].[Na+].[Br:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Br.C1(C)C=CC=CC=1.O>CO>[CH3:1][O:2][CH2:7][C:6]1[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=1[Br:4]

참가 물질

6

반응물 4

HCID 962WaterHCID 1140TolueneHCID 769652-Bromobenzyl bromideHCID 10942334Sodium Methoxide

생성물 1

HCID 129271621-Bromo-2-(methoxymethyl)benzene

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

A temperature of 59.8 g of a 28% solution of sodium methoxide in methanol was raised to 60° C., a mixture solution of 70.4 g of o-bromobenzyl bromide and 70.4 g of methanol was added dropwise, and this was retained at 60° C. for 2 hours. After the mixture was cooled to room temperature, 211 g of toluene and 211 g of water were added thereto, the mixture was stirred, and layers were separated, and an organic layer was recovered. An aqueous layer was extracted with 211 g of toluene three times, the recovered organic layer and 211 g of water were added, and this was washed, and concentrated to obtain 55.3 g of 1-methoxymethyl-2-bromobenzene.

후처리

  1. customlayers were separated
  2. customan organic layer was recovered
  3. extractionAn aqueous layer was extracted with 211 g of toluene three times
  4. additionthe recovered organic layer and 211 g of water were added
  5. washthis was washed
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-679135b220564e1d9893f4a15646e7b7
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252563B2

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