Sodium Cyanide → 1,3-Dioxolane-2-propiononitrile

HRID 888757노트

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HRID 888757 반응식
[C-:1]#[N:2].[Na+].[O:4]1[CH2:8][CH2:7][O:6][CH:5]1[CH2:9][CH2:10]Br>[Cl-].C([N+](C)(C)C)C1C=CC=CC=1.O>[O:4]1[CH2:8][CH2:7][O:6][CH:5]1[CH2:9][CH2:10][C:1]#[N:2]

참가 물질

5

반응물 2

HCID 8929Sodium CyanideHCID 877762-(2-Bromoethyl)-1,3-dioxolane

생성물 1

HCID 780981,3-Dioxolane-2-propiononitrile수율 88%

시약·촉매·용매 2

HCID 5963Benzyltrimethylammonium chloride촉매HCID 962Water용매2회

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온도
90 °C

실험 절차

58.8 g (1.2 mol) of sodium cyanide and 22.28 g (0.12 mol) of benzyltrimethylammonium chloride are dissolved in 360 ml of water. Thereafter 181.03 g (1.0 mol) of 2-[1,3]-dioxolan-2-yl-1-bromoethane are added dropwise and the reaction mixture is heated at 90° C. After six hours it is cooled, diluted with 400 ml of water and subjected to extraction with ether. Drying over magnesium sulfate and evaporation of the solvent give 111.85 g of 3-[1,3]-dioxolan-2-yl-propionitrile as a reddish oil which is used without further purification in the next stage of the reaction.

후처리

  1. temperatureAfter six hours it is cooled
  2. extractionsubjected to extraction with ether
  3. dry with materialDrying over magnesium sulfate and evaporation of the solvent

출처 및 근거

ORD 기록
ord-d57b059543014db88b7fde9cb53bd516
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252784B2

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