Ethanol → 3-(6-(Methylcarbamoyl)pyridin-3-yl)propanoic acid

HRID 889209노트

반응식

HRID 889209 반응식
C([O:8][C:9](=[O:22])[CH:10]=[CH:11][C:12]1[CH:13]=[N:14][C:15]([C:18](=[O:21])[NH:19][CH3:20])=N[CH:17]=1)C1C=CC=CC=1.[CH2:23](O)C>[Pd]>[CH3:20][NH:19][C:18]([C:15]1[CH:23]=[CH:17][C:12]([CH2:11][CH2:10][C:9]([OH:8])=[O:22])=[CH:13][N:14]=1)=[O:21]

참가 물질

4

반응물 2

HCID 702EthanolHCID 667593063-(2-Methylcarbamoyl-pyrimidin 5-yl)acrylic acid benzyl ester

생성물 1

HCID 667602213-(6-(Methylcarbamoyl)pyridin-3-yl)propanoic acid

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

3-(2-methylcarbamoyl-pyrimidin 5-yl)acrylic acid benzyl ester in ethanol (20 mL) in presence of 15 mg of Pd/C, 10%, and stirred under hydrogen balloon overnight to give 3-(2-methylcarbamoyl-pyridine-5-yl)-propionic acid which was used without further purification.

출처 및 근거

ORD 기록
ord-4de765f456134da2ac9a0f3549efe584
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252793B2

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