Nitric Acid → 6-Bromo-3,4-difluoro-2-nitrophenol

HRID 889267노트

반응식

HRID 889267 반응식
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[OH:10].[N+:11]([O-])([OH:13])=[O:12]>S([O-])([O-])(=O)=O.[Ni+].[NH4+].ClCCl>[Br:1][C:2]1[C:3]([OH:10])=[C:4]([N+:11]([O-:13])=[O:12])[C:5]([F:9])=[C:6]([F:8])[CH:7]=1

참가 물질

5

반응물 2

HCID 944Nitric AcidHCID 27362882-Bromo-4,5-difluorophenol

생성물 1

HCID 840832366-Bromo-3,4-difluoro-2-nitrophenol

시약·촉매·용매 2

HCID 171000000CID 171000000촉매HCID 6344Dichloromethane용매

실험 절차

To a round bottom flask containing 2-bromo-4,5-difluorophenol (2.7 g, 12.9 mmol) and ammonium nickel sulfate (2.6 g, 6.46 mmol) is added dichloromethane (15 mL) at RT. A solution of 70% nitric acid (1.2 ml) is added dropwise and the slurry is stirred for 20 to 30 min. The mixture is then quenched with excess MgSO4, filtered and concentrated. The product is used in the next step without purification.

후처리

  1. customThe mixture is then quenched with excess MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe product is used in the next step without purification

출처 및 근거

ORD 기록
ord-c98db8f863d24904825e49ce9dc520a8
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252820B2

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