Dimethylformamide → 2-(6-Bromopyridin-3-yl)acetonitrile
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][N:3]=1.[CH3:10][N:11](C=O)C.[C-]#N.[Na+].[Cl-].[NH4+]>C(OCC)(=O)C>[Br:1][C:2]1[N:3]=[CH:4][C:5]([CH2:8][C:10]#[N:11])=[CH:6][CH:7]=1참가 물질
6
실험 절차
3.75 g (18.2 mmol) of the compound from Example 6A are initially introduced into 20 ml DMF, 979 mg (20.0 mmol) sodium cyanide are added and the mixture is stirred at RT for 2 d. The reaction mixture is introduced on to a mixture of 250 ml saturated ammonium chloride solution and 200 ml ethyl acetate and the aqueous phase is extracted with ethyl acetate (three times with 100 ml each time). The combined organic phases are dried over sodium sulfate, filtered and concentrated and the residue is dried in vacuo. The product obtained in this way is reacted without further purification.
후처리
- additionare added
- extractionthe aqueous phase is extracted with ethyl acetate (three times with 100 ml each time)
- dry with materialThe combined organic phases are dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
- customthe residue is dried in vacuo
- customThe product obtained in this way
- customis reacted without further purification
출처 및 근거
- ORD 기록
- ord-a969a42e32974f22b6062135daa58f5a
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08252817B2
반응 노트
불러오는 중…