참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 3-(Chloromethyl)-2-methylpyridine | HCID 12243711 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(2-Methylpyridin-3-yl)acetonitrile | HCID 19099286 | — |
반응 단계
970 mg (6.85 mmol) of the compound from Example 37A are initially introduced into 10 ml DMF, 336 mg (6.85 mmol) sodium cyanide are added and the mixture is stirred overnight at 45° C. The reaction mixture is introduced on to 75 ml saturated ammonium chloride solution and extracted several times with methylene chloride. The combined organic phases are dried over sodium sulfate, filtered and concentrated. The residue is purified by means of flash chromatography on silica gel (mobile phase: methylene chloride/methanol 20:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08252817B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_08 |
|---|
| ORD ID | ord-3b8056ed72f54a7daab4e4e314dd8c78 |
|---|
| 출처 메모 | uspto-grants-2012_08 |
|---|
