Ethyl Acetate → 2-(4-Amino-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester

HRID 889388노트

반응식

HRID 889388 반응식
[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([F:18])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2].[H][H].C(OCC)(=O)C>[Pd].C(O)C>[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([F:18])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2]

참가 물질

6

반응물 3

HCID 8857Ethyl AcetateHCID 671311902-(3-Fluoro-4-nitro-phenoxy)-2-methyl-propionic acid ethyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 671309762-(4-Amino-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester수율 127.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

10% Palladium on carbon (200 mg) was added to a solution of 2-(3-fluoro-4-nitro-phenoxy)-2-methyl-propionic acid ethyl ester (1.15 g, 4 mmol) in ethanol (20 ml). The suspension was hydrogenated at a hydrogen gas pressure of 1.7 bar for 8 h at ambient temperature. Ethyl acetate was added (100 ml), the solid was filtered off and the filtrate was brought to dryness under reduced pressure to give the title compound (1.23 g, quant.) which was used in the next step without further purification.

후처리

  1. filtrationthe solid was filtered off

출처 및 근거

ORD 기록
ord-29fdff4180c44d04a2fa9ba52ba5d2e7
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252826B2

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