Methanol → HCID 178467367, 화합물

HRID 889526노트

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HRID 889526 반응식
[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[N:26](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:25]=[N:24][N:23]=3)=[CH:12][CH:11]=2)[C:7]2[C:46]([C:50]([O:52][C:53]([O:56][C:57]([O:59][CH2:60][CH2:61][CH:62]([CH3:74])[C@@H:63]([O:70][N+:71]([O-:73])=[O:72])[C@H:64]([O:66][N+:67]([O-:69])=[O:68])[CH3:65])=[O:58])([CH3:55])[CH3:54])=[O:51])=[CH:47][CH:48]=[CH:49][C:6]=2[N:5]=1)[CH3:2].CO>C(Cl)Cl>[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:23][N:24]=[N:25][N:26]=3)=[CH:14][CH:15]=2)[C:7]2[C:46]([C:50]([O:52][C:53]([O:56][C:57]([O:59][CH2:60][CH2:61][CH:62]([CH3:74])[C@@H:63]([O:70][N+:71]([O-:73])=[O:72])[C@H:64]([O:66][N+:67]([O-:69])=[O:68])[CH3:65])=[O:58])([CH3:54])[CH3:55])=[O:51])=[CH:47][CH:48]=[CH:49][C:6]=2[N:5]=1)[CH3:2]

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4

반응물 2

HCID 887MethanolHCID 866470221-[({[(4R,5R)-3-Methyl-4,5-bis(nitrooxy)hexyl]oxy}carbonyl)oxy]-1-methylethyl 2-ethoxy-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

생성물 1

HCID 178467367HCID 178467367, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-[({[(4R,5R)-3-Methyl-4,5-bis(nitrooxy)hexyl]oxy}carbonyl)oxy]-1-methylethyl 2-ethoxy-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate (1.77 g, 1.76 mmol) was dissolved in CH2Cl2 (5 mL) and MeOH was added (30 mL). After stirring at room temperature for 72 hrs, the solution was concentrated under reduced pressure. The residue was purified by flash chromatography (Biotage SP1, SNAP 100 g column, CH2Cl2/MeOH 98:2) affording the tile compound as a white solid.

후처리

  1. concentrationthe solution was concentrated under reduced pressure
  2. customThe residue was purified by flash chromatography (Biotage SP1, SNAP 100 g column, CH2Cl2/MeOH 98:2)

출처 및 근거

ORD 기록
ord-66505e7b3df543068af0e120236d3b2a
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252825B2

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